Takuya Watanabe Selected Research

Alzheimer Disease (Alzheimer's Disease)

11/2023	Kamikihito reduces β-amyloid25-35-induced axon damage via neurotrophic factors.
12/2019	Hippocampal neurons in direct contact with astrocytes exposed to amyloid β25-35 exhibit reduced excitatory synaptic transmission.
1/2017	The Traditional Japanese Herbal Medicine Hachimijiogan Elicits Neurite Outgrowth Effects in PC12 Cells and Improves Cognitive in AD Model Rats via Phosphorylation of CREB.
1/2015	Tumor necrosis factor-α reduces beta-amyloid accumulation primarily by lowering cellular prion protein levels in a brain endothelial cell line.
7/2013	Cholinergic involvement and synaptic dynamin 1 expression in Yokukansan-mediated improvement of spatial memory in a rat model of early Alzheimer's disease.
3/2013	Facilitation of memory impairment and cholinergic disturbance in a mouse model of Alzheimer's disease by mild ischemic burden.
12/2012	Atorvastatin stimulates neuroblastoma cells to induce neurite outgrowth by increasing cellular prion protein expression.
8/2010	Preliminary use of insulin-like growth factor-I as a biomarker for sorting high-dose donepezil responders among Japanese patients with Alzheimer's disease.
7/2010	Dynamin 1 depletion and memory deficits in rats treated with Abeta and cerebral ischemia.
6/2009	Increased plasma urotensin-II and carotid atherosclerosis are associated with vascular dementia.

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Takuya Watanabe Research Topics

Disease

43	Atherosclerosis 06/2021 - 03/2002
31	Neoplasms (Cancer) 02/2024 - 08/2002
21	Atherosclerotic Plaque (Atheroma) 04/2021 - 01/2002
16	Heart Failure 10/2023 - 07/2015
14	Alzheimer Disease (Alzheimer's Disease) 11/2023 - 10/2005
11	Coronary Artery Disease (Coronary Atherosclerosis) 04/2021 - 12/2005
11	Carotid Artery Diseases 05/2019 - 09/2003
9	Insulin Resistance 10/2021 - 03/2008
8	Hypertension (High Blood Pressure) 10/2021 - 10/2005
8	Inflammation (Inflammations) 01/2020 - 01/2016
7	Brain Ischemia (Cerebral Ischemia) 01/2023 - 06/2006
7	Neoplasm Metastasis (Metastasis) 11/2019 - 06/2003
7	Cardiovascular Diseases (Cardiovascular Disease) 01/2018 - 12/2008
6	Stomach Neoplasms (Stomach Cancer) 02/2024 - 06/2003
6	Infections 11/2023 - 04/2005
6	Type 2 Diabetes Mellitus (MODY) 01/2023 - 12/2008
6	Myocarditis (Carditis) 02/2022 - 09/2017
6	Glioma (Gliomas) 01/2020 - 01/2013
6	Vascular Dementia (Subcortical Arteriosclerotic Encephalopathy) 06/2009 - 01/2004
5	Lung Neoplasms (Lung Cancer) 01/2023 - 01/2015
5	Thrombosis (Thrombus) 03/2020 - 05/2000
5	Amyloid Plaque 12/2019 - 06/2006
5	Dementia (Dementias) 03/2018 - 01/2004
5	Glioblastoma (Glioblastoma Multiforme) 01/2015 - 02/2009
5	Intervertebral Disc Degeneration 05/2008 - 11/2005
5	Essential Hypertension 02/2007 - 03/2002
4	Anemia 11/2023 - 08/2018
4	Cardiomyopathies (Cardiomyopathy) 08/2023 - 09/2015
4	Hepatocellular Carcinoma (Hepatoma) 01/2023 - 01/2013
4	Stroke (Strokes) 09/2022 - 11/2007
4	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2022 - 07/2018
4	Hyperplasia 04/2021 - 05/2000
4	Synovial Sarcoma (Synovioma) 10/2012 - 12/2005
3	Colorectal Neoplasms (Colorectal Cancer) 03/2024 - 10/2011
3	Cardiogenic Shock 11/2023 - 09/2017
3	Hemorrhage 03/2023 - 12/2019
3	Transient Ischemic Attack 01/2023 - 03/2013
3	Pulmonary Hypertension 01/2023 - 01/2009
3	Ischemia 06/2021 - 06/2006
3	Cerebral Infarction 02/2018 - 09/2009
3	Obesity 01/2017 - 12/2008
3	Body Weight (Weight, Body) 01/2015 - 07/2012
2	Diarrhea 03/2024 - 12/2019
2	Respiratory Insufficiency (Respiratory Failure) 01/2024 - 01/2020
2	Myasthenia Gravis 01/2024 - 02/2022

Drug/Important Bio-Agent (IBA)

21	Peptides (Polypeptides)IBA 06/2021 - 03/2002
16	Glucose (Dextrose)FDA LinkGeneric 01/2023 - 04/2005
15	Apolipoproteins E (ApoE)IBA 04/2021 - 09/2010
12	Proteins (Proteins, Gene)FDA Link 01/2020 - 11/2002
12	oxidized low density lipoproteinIBA 01/2015 - 01/2002
11	ApolipoproteinsIBA 06/2021 - 10/2008
11	urotensin IIIBA 06/2009 - 07/2002
10	Biomarkers (Surrogate Marker)IBA 01/2023 - 06/2009
10	Vasoconstrictor AgentsIBA 01/2020 - 10/2005
5	Cholinergic Agents (Cholinergics)IBA 03/2024 - 01/2008
5	Insulin (Novolin)FDA Link 10/2021 - 09/2003
5	CollagenIBA 02/2018 - 11/2010
5	Amyloid beta-PeptidesIBA 01/2015 - 06/2006
5	LipidsIBA 01/2015 - 08/2002
5	Insulin-Like Growth Factor I (IGF-1)IBA 08/2010 - 09/2003
4	Tyrosine (L-Tyrosine)FDA Link 01/2020 - 05/2009
4	Paclitaxel (Taxol)FDA LinkGeneric 07/2018 - 06/2003
4	Acetylcholine (Acetylcholine Chloride)FDA Link 03/2018 - 06/2006
4	AntibodiesIBA 01/2018 - 04/2005
4	CholesterolIBA 01/2018 - 04/2007
4	DNA (Deoxyribonucleic Acid)IBA 03/2009 - 01/2002
4	Serotonin (5 Hydroxytryptamine)IBA 11/2007 - 01/2002
3	Irinotecan (Camptosar)FDA LinkGeneric 03/2024 - 04/2007
3	Sodium-Glucose Transport ProteinsIBA 01/2023 - 01/2015
3	Amyloid (Amyloid Fibrils)IBA 01/2023 - 03/2013
3	Glycated Hemoglobin (Glycosylated Hemoglobin)IBA 01/2023 - 01/2015
3	Cyclosporine (Ciclosporin)FDA LinkGeneric 02/2022 - 03/2011
3	InterferonsIBA 04/2021 - 09/2006
3	Erythropoietin FDA Link 01/2020 - 05/2000
3	Phosphotransferases (Kinase)IBA 01/2020 - 01/2013
3	Peptide Hydrolases (Proteases)FDA Link 10/2019 - 10/2003
3	Coffee FDA Link 07/2019 - 07/2006
3	Yi-Gan SanIBA 01/2019 - 07/2013
3	Cisplatin (Platino)FDA LinkGeneric 10/2018 - 04/2007
3	Hormones (Hormone)IBA 05/2018 - 04/2004
3	salicylhydroxamic acid (SHAM)IBA 03/2018 - 03/2011
3	Angiotensin IIIBA 08/2016 - 07/2002
3	Glucagon-Like Peptide 1 (GLP 1)IBA 04/2014 - 07/2012
3	Prion ProteinsIBA 12/2012 - 10/2010
3	Donepezil (Aricept)FDA LinkGeneric 08/2010 - 06/2006
3	Messenger RNA (mRNA)IBA 02/2009 - 05/2000
3	Lipoprotein(a)IBA 04/2005 - 01/2004
3	Lipid PeroxidesIBA 04/2005 - 01/2004
3	LDL CholesterolIBA 04/2005 - 01/2004
2	Cholinergic ReceptorsIBA 01/2024 - 02/2022

Therapy/Procedure

27	Therapeutics 01/2024 - 06/2003
25	Heart-Assist Devices 10/2023 - 06/2014
6	Extracorporeal Membrane Oxygenation 11/2023 - 09/2017
5	Transplantation 01/2022 - 11/2005
5	Heart Transplantation (Grafting, Heart) 09/2019 - 06/2013
4	Operative Surgical Procedures 01/2023 - 01/2021
4	Drug Therapy (Chemotherapy) 07/2018 - 10/2012
3	Gastrectomy 02/2024 - 04/2011
3	Chemoradiotherapy 12/2021 - 07/2013
3	Radiotherapy 07/2020 - 10/2012